منابع مشابه
Amide-Amide and Amide-Water Hydrogen Bonds: Implications for Protein Folding and Stability.
Amide-amide hydrogen bonds have been implicated in directing protein folding and enhancing protein stability. Inversion transfer (13)C NMR spectroscopy and IR spectroscopy were used to compare the ability of various amide solvents and of water to alter the rate of the cis-trans isomerization of the prolyl peptide bond of Ac-Gly-[β,δ-(13)C]Pro-OMe and the amide I vibrational mode of [(13)C=O]Ac-...
متن کاملDependence of amide vibrations on hydrogen bonding.
The effect of hydrogen bonding on the amide group vibrational spectra has traditionally been rationalized by invoking a resonance model where hydrogen bonding impacts the amide functional group by stabilizing its [(-)O-C=NH (+)] structure over the [O=C-NH] structure. However, Triggs and Valentini's UV-Raman study of solvation and hydrogen bonding effects on epsilon-caprolactum, N, N-dimethylace...
متن کاملStrong Hydrogen Bonding to the Amide Nitrogen Atom in an "Amide Proton Sponge": Consequences for Structure and Reactivity
The carbonyl oxygen atom of the amide functional group is universally believed to be the thermodynamically preferred site of protonation in amides;[1] however, N protonation has been proposed to play a key role in biologically important reactions of peptides and proteins such as acid-catalyzed peptide hydrolysis[2] and cis ± trans isomerization about the CÿN bond.[3] Extensive research into the...
متن کاملAmide Proton Solvent Protection in Amylin Fibrils Probed by Quenched Hydrogen Exchange NMR
Amylin is an endocrine hormone that accumulates in amyloid plaques in patients with advanced type 2 diabetes. The amyloid plaques have been implicated in the destruction of pancreatic β-cells, which synthesize amylin and insulin. To better characterize the secondary structure of amylin in amyloid fibrils we assigned the NMR spectrum of the unfolded state in 95% DMSO and used a quenched hydrogen...
متن کاملThe synthesis of a pyridine-N-oxide isophthalamide rotaxane utilizing supplementary amide hydrogen bond interactions.
The synthesis of a pyridine-N-oxide containing rotaxane, not requiring an additional ionic template, has been achieved in 32% yield. Successful rotaxane formation is dependent upon the structure of the isophthalamide macrocycle used, an observation which has been rationalised by a combination of NMR spectroscopy, X-ray crystallography and computational modelling.
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ژورنال
عنوان ژورنال: Acta Crystallographica Section A Foundations of Crystallography
سال: 2012
ISSN: 0108-7673
DOI: 10.1107/s0108767312095815